This book constitutes the refereed post-proceedings of the Second IFIP WG 12.7 International Workshop on Computational History and Data-Driven Humanities, held in Dublin, Ireland, in May 2016. The 7 full papers presented together with 2 invited talks and 4 lightning talks were carefully reviewed and selected from 14 submissions. The papers focus on the challenge and opportunities of data-driven humanities and cover topics at the interface between computer science, social science, humanities, and mathematics.