This book constitutes the refereed proceedings of the Second International Conference on Intelligence Science, ICIS 2017, held in Shanghai, China, in October 2017. The 38 full papers and 9 short papers presented were carefully reviewed and selected from 82 submissions. They deal with key issues in intelligence science and have been organized in the following topical sections: theory of intelligence science; cognitive computing; big data analysis and machine learning; machine perception; intelligent information processing; and intelligent applications.