This book constitutes the proceedings of the 28th International Tyrrhenian Workshop on Digital Communication, TIWDC 2017, which took place in Palermo, Italy, in September 2017. The 18 papers presented in this volume were carefully reviewed and selected from 40 submissions. They were organized in topical sections named: biometric systems; emerging services with Network Function Virtualization (NFV); multimedia forensics; security protocols; software defined networks; and technologies for Internet of Things (IoT).