This book constitutes the thoroughly refereed post-conference proceedings of the International Conference for Smart Health, ICSH 2015, held in Phoenix, AZ, USA, in November 2015. The 33 papers presented together were carefully reviewed and selected from 43 submissions. The conference focused on topics and issues including medical monitoring and information extraction, clinical and medical data mining, health data analysis and management, big data and smart health, and healthcare intelligent systems and clinical practice.