Chapter 1. Introduction -- Chapter 2. The Psychiatrist and Pathologist Aloysius Alzheimer and His Seminal Findings -- Chapter 3. Alzheimer's Disease Research After 1945: The Recommencement -- Chapter 4. Alzheimer's Research Goes Deeper - Ultrastructural Electron Microscopy Studies -- Chapter 5. Focus on Neurochemistry Led to the Cholinergic Hypothesis of Alzheimer's Disease -- Chapter 6. The Glutamatergic-Hypothesis of Alzheimer's Disease -- Chapter 7. Biochemistry and Genetics Points Out a Prime Suspect for Causing Alzheimer's Disease -- Chapter 8. Getting to the Bottom of It: Amyloid Beta Peptide Is Derived from a Larger Precursor -- Chapter 9. Step by Step Towards an Amyloid Beta Peptide-Based Hypothesis of Alzheimer's Disease -- Chapter 10. Concerns about the Amyloid Cascade Hypothesis and Reappraisals -- Chapter 11. Ignorance or Conspiracy? Or Just an Amyloid Firewall that Blocks Alternative Ideas? -- Chapter 12. In the Slip Stream of Amyloid: The Tau and Tangle Hypothesis -- Chapter 13. Focus on Tauopathies and Beyond -- Chapter 14. Alzheimer's Research Gains Momentum and Spreads Out -- Chapter 15. The Amyloid Cascade Hypothesis Has to Deliver, Finally -- Chapter 16. Beyond APP, PSEN1, PSEN2, and APOE: What Else Does the Genome Tell Us? Chapter 17. Alternative Hypotheses and Observations that were Somehow Lost on the Way -- Chapter 18. Is the Persistence of the Amyloid Cascade Hypothesis a Result of Constant Confirmation Bias? -- Chapter 19. Driving Forces of Alzheimer's Research Directions -- Chapter 20. Thirty Years after the Launch of the Amyloid Cascade Hypothesis: Is There a Shift of Gears at Last? -- Chapter 21. "If You Change the Way You Look at Things, Things You Look at Change".