chapter 1 Redox-Genome Interactions: Evolution of a Concept / chapter 2 Measurements of Biological Reducing Power by Voltammetric Methods / chapter 3 Composition and Regulation of Thiol-Disulfide Redox State / chapter 4 Thiols and Thioredoxin in Cellular Redox Control -- chapter 5 Role of Free Radicals and Cellular Redox Status in Signal Transduction and Gene Expression -- chapter 6 Redox Regulation of Apoptosis / chapter 7 Mitochondria, Aging, and Disease: A Genomic Perspective -- chapter 8 The Human Genome as a Target of Oxidative Modification: Damage to Nucleic Acids -- chapter 9 Redox Modulation in Tumor Initiation, Promotion, and Progression / chapter 10 The Potential Impact of Polymorphism on Oxidative Stress Status -- chapter 11 Mitochondrial Dysfunction in Genetic Diseases / chapter 12 Oxidative and Nitrosative Stress in Cystic Fibrosis: Significance or Triviality? -- chapter 13 Oxyradicals in Iron Overload Syndromes: Hemochromatosis / chapter 14 Oxidative Imbalance in Hereditary Hemoglobinopathies: The Role of Reactive Oxygen Species -- chapter 15 Association of Oxidative Stress with Cataractogenesis / chapter 16 Oxidative Stress and Age-Related Macular Degeneration / chapter 17 Retinitis Pigmentosa: A Potential Role for Reactive Oxygen and Nitrogen Species During Photoreceptor Apoptosis -- chapter 18 The Role of Oxidative Imbalance in the Pathogenesis of Down Syndrome / chapter 19 Metal Homeostasis and Its Relation to Oxidative Stress in Alzheimer's Disease -- chapter 20 Oxidative Stress and Huntington's Disease / chapter 21 Oxidative Stress in Familial Amyotrophic Lateral Sclerosis / chapter 22 Oxidants and Antioxidants in the Pathology of Colon Cancer / chapter 23 The Role of Oxidative Imbalance in Diabetes Mellitus / chapter 24 The Role of Reactive Oxygen Species, the Renin-Angiotensin System, and Endothelin in the Development of Essential Hypertension -- chapter 25 Oxidative Stress in Cardiovascular Disease: Role of Oxidized Lipoproteins in Macrophage Foam Cell Formation and Atherosclerosis -- chapter 26 Free Radicals in Rheumatoid Arthritis: Mediators and Modulators.