PART ONE: BASIC CONSIDERATIONS OF VENOUS DISORDERS 1. Venous and lymphatic disease: a historical review 2. Development and anatomy of the venous system 3. The physiology and hemodynamics of the normal venous circulation 4. Classification and etiology of chronic venous disease 5. The physiology and hemodynamics of chronic venous insufficiency of the lower limb 6. Pathogenesis of varicose veins and cellular pathophysiology of chronic venous insufficiency 7. Venous ulcer formation and healing at cellular levels 8. Acute venous thrombosis: pathogenesis and evolution 9. The epidemiology of and risk factors for acute deep venous thrombosis 10. Epidemiology of chronic venous disorders PART TWO: DIAGNOSTIC EVALUATIONS AND VENOUS IMAGING STUDIES 11. Evaluation of hypercoagulable states and molecular markers of acute venous thrombosis 12. Duplex ultrasound scanning for acute venous disease 13. Duplex scanning for chronic venous obstruction and valvular incompetence 14. Evaluation of venous function by indirect noninvasive tests (plethysmography) 15. Lower extremity ascending and descending phlebography 16. Computed tomography and magnetic resonance imaging in venous disease PART THREE: MANAGEMENT OF ACUTE THROMBOSIS 17. The clinical presentation and the natural history of acute deep venous thrombosis 18. Diagnostic algorithm for acute deep venous thrombosis and pulmonary 19. Medical treatment of acute deep venous thrombosis and pulmonary embolism 20. Catheter-directed thrombolysis for treatment of acute deep venous thrombosis 21. Surgical thrombectomy and percutaneous mechanical thrombectomy for treatment of acute iliofemoral deep venous thrombosis