Drug Development in Psychiatry: The Long and Winding Road from Chance Discovery to Rational Development -- The History of Drug Development in Psychiatry: A Lesson in Serendipity -- The Evolving Role of Animal Models in the Discovery and Development of Novel Treatments for Psychiatric Disorders -- Discovery and Development of Monoamine Transporter Ligands -- Drug Development for New Psychiatric Drug Therapies -- Post-Approval Research in Drug Development: Priorities and Practices -- Discovery of new transmitter systems and hence new drug targets -- Reverse engineering drugs -- Back to the Future of Neuropsychopharmacology -- Targeted Treatments for Fragile X Syndrome -- The Difficult Path to the Discovery of Novel Treatments in Psychiatric Disorders Diseases -- Biomarkers in Psychiatric Drug Development: From Precision Medicine to Novel Therapeutics -- The role of fMRI in drug development: an update -- Monoamine Oxidase B (MAO-B): A Target for Rational Drug Development in Schizophrenia Using PET Imaging as an Example -- Genomics in Treatment Development -- Increased Inflammation and Treatment of Depression: from Resistance to Reuse, Repurposing and Redesign -- Experimental medicine approaches in early phase CNS drug development.