chapter 1 Process Chemistry in the Pharmaceutical Industry: Challenges in an Ever Changing Climate—An Overview -- chapter 2 Emerging Trends in Process Chemistry -- chapter 3 Varenicline: Discovery Synthesis and Process Chemistry Developments -- chapter 4 The SUTENT® Story -- chapter 5 An Efficient and Scalable Process for the Preparation of a Potent MC4 Receptor Agonist -- chapter 6 Process Research and Development of LY414197, a 5HT 2B Antagonist -- chapter 7 To Overcome the Hurdles: Coping with the Synthesis of Robalzotan, a Complex Chroman Antidepressant* -- chapter 8 Chiral Amine Synthesis—Strategies, Examples, and Limitations -- chapter 9 Unnatural Amino Acids -- chapter 10 The Chemical Development of a Potential Manufacturing Route to the Endothelin Antagonists UK-350,926 and UK-349,862 -- chapter 11 Cefovecin Sodium: A Single-Dose Long-Acting Antibiotic for Use in Companion Animals -- chapter 12 The Lithium–Halogen Exchange Reaction in Process Chemistry -- chapter 13 Oxetan-3-one: Chemistry and Synthesis -- chapter 14 Well-Defined (NHC)Pd (II) Complexes and Their Use in C–C and C–N Bond-Forming Reactions -- chapter 15 Toward Truly Efficient Organic Reactions in Water -- chapter 16 The Chemical Development of the Commercial Route to Sildenafil Citrate -- chapter 17 Stereoselective Enzymatic Synthesis of Intermediates Used for Antihypertensive, Antiinfective, and Anticancer Compounds -- chapter 18 Designing Robust Crystallization Processes for Active Pharmaceutical Ingredients—From Art to Science -- chapter 19 Mid-Infrared Spectroscopy for Process Development -- chapter 20 Optimizing an Asymmetric Homologation in a Tandem Asymmetric Homologation–Homoaldol Process -- chapter 21 Development of Efficient One- Pot Process in the Synthesis of Sitagliptin: Application of Online-Infrared for Kinetic Studies to Probe the Reaction Mechanism -- chapter 22 Mid-Infrared Monitoring Applications during Development of the Vinyl Ether Formation Step in the Preparation of Aprepitant (Emend) -- chapter 23 Process Analytical Technology in the Manufacture of Bulk Active Pharmaceuticals—Promise, Practice, and Challenges -- chapter 24 PEGylation of Biological Macromolecules -- chapter 25 Microwave Technology in Process Optimization -- chapter 26 Process Development Considerations for Therapeutic Monoclonal Antibodies in Mammalian Cell Culture -- chapter 27 Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining Pharmaceutical Reaction Steps -- chapter 28 Trends in Outsourcing -- chapter 29 Sourcing Pharmaceutical Products in China and India.