This book constitutes the proceedings of the 29th International Conference on Architecture of Computing Systems, ARCS 2016, held in Nuremberg, Germany, in April 2016. The 29 full papers presented in this volume were carefully reviewed and selected from 87 submissions. They were organized in topical sections named: configurable and in-memory accelerators; network-on-chip and secure computing architectures; cache architectures and protocols; mapping of applications on heterogeneous architectures and real-time tasks on multiprocessors; all about time: timing, tracing, and performance modeling; approximate and energy-efficient computing; allocation: from memories to FPGA hardware modules; organic computing systems; and reliability aspects in NoCs, caches, and GPUs.