This book constitutes the refereed post-conference proceedings of the 18th International Conference on Evaluation of Novel Approaches to Software Engineering, ENASE 2023, held in Prague, Czech Republic, during April 24-25, 2023. The 15 revised full papers presented in these proceedings were carefully reviewed and selected from 121 submissions. They contribute to the understanding of relevant trends of current research on Evaluation of Novel Approaches to Software Engineering, including: requirements engineering, artificial intelligence development, natural language processing, autonomous systems, model-driven development, product line engineering, software patterns, software metrics, quality assurance, and process management.