part Part 1 Introduction -- chapter 1 Introduction -- György Kéri and István Toth / part Part 2 Pathomechanisms and molecular target finding -- chapter 2 Drug discovery based on functional genomics -- Gábor Mikala and István Vályi-Nagy / chapter 3 Mapping of the human genome / chapter 4 Molecular diagnosis of signal transduction related diseases / part Part 3 Common pathway and general mechanism -- chapter 5 Signal transduction therapy / chapter 6 Heat shock proteins / chapter 7 Transcription factors as targets for drug development / chapter 8 Apoptosis in various diseases / chapter 9 Caspases -- Pál I. Bauer, Erzs�bet Kénesi and Andr's Ill's / chapter 10 The role of drug metabolism enzymes in signal transduction processes / chapter 11 Recent developments in calcium signaling -- Greg Monteith / chapter 12 T-cell receptors and coreceptors; cytokine receptors / chapter 13 Neuro-immune responses in different diseases role of tumor necrosis factor- and IL-I -- SZILVESZTER E. VIZI / chapter 14 Regulation of B lymphocyte function by crosstalk between receptors with stimulatory and inhibitory activity / part Part 4 Drug discovery -- chapter 15 Combinatorial chemistry / chapter 16 Lead search, selection and optimization in silico (virtual) screening / chapter 17 The development of carbohydrate based therapeutics / chapter 18 Introduction to structure and ligand-based drug design / chapter 19 Gene therapy / part Part 5 Molecular pathomechanism of cancer -- chapter 20 Cancer genetics / chapter 21 Cancer as a communication disorder / part Part 6 Infectious diseases -- chapter 22 Human immunodeficiency virus -- Chris Birch / chapter 23 Signal transduction in virus infected cells -- Peter Krajcsi / chapter 24 The development of vaccines to prevent rheumatic fever / chapter 25 Systemic antifungal agents / part Part 7 Diseases of the central and the peripheral nervous system -- chapter 26 Mechanisms of neurodegenerative diseases / chapter 27 Neurobiology of pain -- Maree Smith / chapter 28 Capsaicin receptors as target molecules on nociceptors for development of novel analgesic agents / chapter 29 Migraine / chapter 30 Regulatory mechanisms in focal ischemic stroke / chapter 31 Signal transduction abnormalities in epilepsies / chapter 32 Parkinson's disease -- Michael S. Starr / chapter 33 Physiological role of amyloid precursor protein (APP) and -amyloid peptides B. PENKE AND T. HARKÁNY -- chapter 34 Eye diseases / part Part 8 Cardiovascular diseases -- chapter 35 Atherosclerosis / chapter 36 Disorders of the blood coagulation f ibrinolytic system RAYMUND MACHOVICH / chapter 37 Angiogenesis / part Part 9 Endocrinal and gastrointestinal disorders -- chapter 38 Diabetes and the heart / chapter 39 The leptin hormonal system as a target for new drugs designed to control food intake and body weight / chapter 40 Regulation of gastric secretion, Helicobacter pylori and inflammation of the gastric epithelium / chapter 41 Osteoporosis / part Part 10 Drug applications -- chapter 42 Modulation of drug effects by ABC transporters / chapter 43 Peptide or protein based drug delivery and targeting systems / chapter 44 Current approaches to peptidomimetics / chapter 45 Drug delivery systems utilizing lipids and sugars / chapter 46 Pharmacokinetic-pharmacodynamic modeling and an example of its application to drug delivery