This book contains select papers presented during the 6th National Conference on Multidisciplinary Analysis and Optimization. The book focuses on design and analysis as applicable to optimization of engineering systems in aerospace, mechanical, automotive, manufacturing, biomedical, and other domains. The book includes papers on the topics such as metamodeling or surrogate modeling, systems design and optimization, optimization and additive manufacturing, mixed integer and linear programming, multiscale and multiphysics problems, among others. The book can be a valuable reference for researchers and professionals interested in the field of optimization and its use in design for different applications.