Part I. Epidemiology -- Overview of metabolic syndrome -- Obesity in the United States -- Obesity in Latin America -- Obesity in Sub-Saharan Africa -- Obesity in Middle East -- Obesity in South Asia -- Obesity in East Asia -- Part II. Genetic Factors -- Evolution of obesity -- Genetics of obesity -- Genetics of type 2 diabetes -- Genetics of lipid disorders -- Genetics of cardiovascular risk in obesity -- Part III. Environmental Factors -- Fetal metabolic programming -- Childhood environment and obesity -- Diet and obesity -- The built environment and obesity -- Community networks and obesity -- Part IV. Pathophysiology -- Principles of energy homeostasis -- Carbohydrate, protein and fat metabolism in obesity -- Brain regulation of feeding and metabolism -- Adipose structure (white, brown, beige) -- Adipokines and Metabolism -- Gut hormones and obesity -- Gut microbiome, obesity and metabolic syndrome -- Pancreatic islet adaptation and failure in obesity -- Insulin resistance in obesity -- Linking inflammation, obesity and metabolic syndrome -- Dyslipidemia in obesity -- Myokines and metabolism -- Circadian rhythms and metabolism -- Sleep disruption and obesity -- Intermittent fasting and time restricted eating -- Part V. Diseases Associated with Obesity -- Body composition assessment -- Type 2 diabetes: etiology, epidemiology, pathogenesis, treatment -- Obesity and cardiac disease -- Nonalcoholic fatty liver disease -- Metabolic syndrome, GERD, Barrett's esophagus -- Sarcopenic obesity -- Obstructive sleep apnea and other respiratory diseases in obesity -- Reproductive disorders in obesity -- Obesity, metabolic dysfunction and dementia -- Linking obesity, metabolism and cancer -- Endocrine disorders associated with obesity -- Kidney disease in obesity and metabolic syndrome -- Part VI. Prevention and Treatment -- Diet, exercise and behavior therapy -- Pharmacotherapy of obesity and metabolic syndrome -- Bariatric surgery -- Prevention and treatment of childhood obesity and metabolic syndrome -- Global,national and community obesity prevention programs.