This practical textbook is intended to be a hands-on guide for healthcare simulation personnel to better enable them to both appreciate the values of equity, diversity, and inclusion (EDI) in healthcare education and to bring those concepts to life in their respective simulation-based teaching and training. The first section of this textbook grounds readers in the concepts of EDI within healthcare education. The second section provides practical ideas and the theoretical background to integrate these concepts into the programming of a simulation program. This section includes topics related to staff recruiting, appropriate mannequin and moulage diversity, creating patient scenarios, mitigating biases, and inclusive debriefing, among others. The final section brings EDI concepts to life with dozens of real-life programs, providing simulation examples, concepts, and principles focused on a diverse range of patients and their needs. These simulation case studies include simulator diversity, interprofessional sessions, the use of virtual reality simulation, team development, specific patient examples, and a checklist for bias. This textbook ensures that the next generation of healthcare professionals are trained in accordance with EDI principles, and even more importantly, that they are prepared to approach their future patients in an equitable and inclusive way.