Chapter 1: Protein Networks in Human Disease -- Chapter 2: Protein-Protein Interactions in Cancer -- Chapter 3: Protein-Protein Interactions in Neurodegenerative Diseases -- Chapter 4: Protein-Protein Interactions in Immune Disorders and Inflammation -- Chapter 5: PPIs in Host-Pathogen Interactions -- Chapter 6: Drug Design methods to regulate protein-protein interactions -- Chapter 7: Small molecule inhibitors of Protein-Protein Interactions as Therapeutics.