![High-throughput lead optimization in drug discovery için kapak resmi High-throughput lead optimization in drug discovery için kapak resmi](/client/assets/5.0.0.9/ctx//client/images/no_image.png)
Başlık:
High-throughput lead optimization in drug discovery
Yazar:
Kshirsagar, Tushar.
ISBN:
9781420006964
Yayın Bilgileri:
Boca Raton : CRC Press, c2008.
Fiziksel Tanımlama:
ix, 243 p. : ill.
Seri:
Critical reviews in combinatorial chemistry
Seri Başlığı:
Critical reviews in combinatorial chemistry
İçerik:
Application of parallel synthesis to the optimization of inhibitors of the ZipA-FtsZ protein-protein interaction / Lee D. Jennings -- Case studies of parallel synthesis in hit identification, hit exploration, hit-to-lead, and lead optimization programs / Alexander Ernst and Daniel Obrecht -- A successful application of parallel synthesis to computer-assisted structural optimization of new leads targeting human immunodeficiency virus-1 reverse transcriptase : the case of acylthiocarbamates and thiocarbamates / Angelo Ranise, Andrea Spallarossa, and Sara Cesarini -- How high-throughput medicinal chemistry can expedite lead discovery, lead optimization, and beyond / Rongshi Li -- Rapid lead identification of inhibitors of adenine nucleotide translocase: a case study of applying combinatorial chemistry techniques in drug discovery / Yazhong Pei, Walter H. Moos, and Soumitra Ghosh -- Parallel synthesis of anticancer, antiinflammatory, and antiviral agents derived from L- and D-amino acids / Robert C. Reid and David P. Fairlie -- Application of solid-phase parallel synthesis in lead optimization studies / Bijoy Kundu -- High-throughput solid-phase synthesis of nucleoside-based libraries in the search for new antibiotics / Dianqing Sun and Richard E. Lee.
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