Part I.Covid-19 Pandemic -- 1.Covid-19: Pandemic effect on Reproduction (Yaakov Ben-tov and Joseph G. Schenker) -- 2. COVID-19 pandemic and vaccination (Yonatan Oster) -- 3. Pregnancy: legal and ethical issues of vaccine refusal (Abraham Steinberg) -- Part II. Beginning of Human Life -- 4. Scientific and religious controversies on beginning of human life (Asim Kurjak) -- 5 .Philosophical consideration about the beginning of human life (Frank Chervenak and Amos Grunenbaum) -- Part III. Rights to Reproduce -- 6. ART- Right to reproduce (Frankel RA, Merkison J, DeCherney AH) -- 7. Surrogate Pregnancies: Medical, Ethical, Legal and Religious Aspects (Einat Gutman- Ido and Joseph. G. Schenker) -- 8.Human Reproductive Cloning(Benagiano G and Bianchi P) -- 9.The Postmenopausal mother (Bitzer I) -- 10. Sex Preselection (Serour Gamal) -- 11. Planned oocyte cryopreservation -Social aspects (Tzafril A and Hyman I) -- 12. Medical ,Social, Legal', Religious Aspects of Genetic Material Donation (Yoel Shufaro, Alyssa Hochberg, Joseph G Schenker) -- 13. Legal Aspects of ART - Informed Consent (Golan Ofra) -- Part IV. Innovative Technologies -- 15. Artificial Intelligence in reproductive medicine (Assaf Ben-Meir, Natali Schachter-Safrai) -- 15. PGT -A also known as PGS - the indication (Schmutzler A) -- 16. In vitro oocyte maturation (Tan Justin and Tan SL) -- 17. Medical and ethical aspects of Non-invasive Prenatal Diagnosis (NIPT) (Wolfgang Holzgreve) -- 18. Embryo Specific Communication and Interaction with Maternal Environment (Barnea Eytan) -- Partr V. Some Difficult Patients -- 19. Management of infertility in overweight or obese PCOS patients (Xiangyan Ruan,Yu Yang, Muqing Gu, and Pooja Dhunge) -- 20. Ethical issues in fertility sparing treatments in Gynecological Oncology (Simoncini Tommaso, Caretto Marta).