Part I Introduction -- A short history of chromosome rearrangements and gene fusions in cancer -- Part II General -- Molecular genetics methods in discovery of chromosome structure -- Mechanism of recurrent chromosomal translocations -- Chromosome translocations, cancer initiation and clonal evolution -- Chromosomal fragile sites and cancer -- Copy number changes in carcinomas: applications -- Part III LEUKAEMIA/LYMPHOMA -- Chronic myeloid leukaemia -- Immunoglobulin and MYC rearrangements in multiple myeloma pathogenesis -- Genetic alterations in B cell lymphoma -- Chromosomal translocations and gene rearrangements in acute lymphoblastic leukaemia -- Cellular and molecular basis of MLL leukaemias: from transformation mechanisms to novel therapeutic strategies -- Acute promyelocytic leukaemia: from a specific translocation to cure by targeted therapies -- Chromosome Abnormalities in AML and their clinical importance -- PART IV SARCOMAS -- Fusion Oncogenes of Sarcomas -- Translocations in Ewing Sarcoma -- PART V EPITHELIAL TUMOURS -- RET and thyroid carcinomas -- Gene fusions in prostate cancer -- Chromosomal Translocations in Lung Cancer -- Colon & Ovarian translocations -- PART VI OTHER ASPECTS -- Pre-clinical modeling of chromosomal translocations and inversions -- Protein complex hierarchy & translocation gene products -- Aberrant transcriptional programming in blood cancers -- Index.