chapter Drug Development of Inhaled Steroids A Pharmacologist’s View Based on Experiences from the Budesonide Project -- chapter 2 How Inhaled Corticosteroids Changed Asthma Therapy -- chapter 3 Side Effects of Inhaled Corticosteroids -- chapter 4 Mechanisms of Gene Regulation by the Glucocorticoid Receptor -- chapter 5 Relationship of Dose- and Time-Dependent Corticosteroid Responses to Receptor Turnover -- chapter Blockade of Chemokine Production /Function as an Example of Glucocorticoid Anti-in.ammatory Actions -- chapter 7 Newly Recognized Glucocorticoid Targets -- chapter 8 Aerosol Delivery Devices and Airways/Lung Deposition -- chapter 9 Uptake, Retention, and Biotransformation of Corticosteroids in the Lung and Airways -- chapter 10 Systemic Disposition and Effects of Inhaled Corticosteroids -- chapter 11 Extrapulmonary Effects of Inhaled Corticosteroids -- chapter 12 Factors Involved in the Pulmonary Targeting of Inhaled Glucocorticoids: The Use of Pharmacokinetic/ Dynamic Simulations / chapter Reversible Glucocorticoid Esteri.cation -- chapter 14 Airway Selectivity of Current Inhaled Corticosteroids in Properly Designed Studies -- chapter 15 Childhood Asthma and Growth -- chapter 16 Evaluation and Comparison of Inhaled Steroids -- chapter 17 The Role of Direct Assessment of Airway Inflammation in Evaluating Inhaled Glucocorticosteroid Efficacy and in Managing the Asthmatic Patient / chapter Use of Exhaled Nitric Oxide as Readout for Inhaled Corticosteroid Ef.cacy -- chapter 19 Markers of Systemic Actions of Corticosteroids -- chapter 20 Patient Adherence to Inhaled Corticosteroid Therapy -- chapter Prospects for Developing Inhaled Steroids with Extrahepatic Metabolism “Soft Steroids” -- chapter 22 Design and Development of a Soft Corticosteroid, Loteprednol Etabonate -- chapter 23 Development of Inhaled Steroids Based Upon Prodrugs with Prolonged Intraluminal Retention Time -- chapter Transcription Factors AP-1 and NF-kB as Targets for Development of Anti-in.ammatory Drugs -- chapter 25 Remodeling and the Effects of Steroids in Asthma -- chapter 26 Inhaled Corticosteroids and the Natural History of Asthma -- chapter 27 Combination Therapies Using Inhaled Corticosteroids.