Part I. Normal Cardiac Rhythm and Pacemaker Activity -- Chapter 1. Cardiac Ion Channels and Heart Rate and Rhythm -- Chapter 2. A Historical Perspective on the Development of Models of Rhythm in the Heart -- Chapter 3. Ionic Basis of the Pacemaker Activity of SA Node Cell Revealed by the Lead Potential Analysis -- Chapter 4. The "Funny" Pacemaker Current -- Chapter 5. Cardiac Pacemaking is an Emergent Property of Complex Synchronized Signaling on Multiple Scales -- Chapter 6. Unique Features of the Human Sinoatrial Node Structure, Function and Arrhythmias: Mechanistic Insights from Integrated 3D Mapping Approaches -- Chapter 7. Mechano-Electric Coupling in the Heart: Effects on Heart Rate and Rhythm -- Part II. Neurocardiac Axis and Arrhythmias -- Chapter 8. Fundamental Neurocardiology: The Intracardiac Nervous System -- Chapter 9. The Neuro-cardiac Axis in Arrhythmogenesis: Role and Impact of Autonomic Modulation -- Part III. Role of Specific Channels and Subcellular Structures in Arrhythmia -- Chapter 10. L-type Ca2+ Channels and Cardiac Arrhythmias -- Chapter 11. Kv11.1 (hERG1) Channels and Cardiac Arrhythmia -- Chapter 12. TRP Channels in Cardiac Arrhythmia: Their Role During Purinergic Activation Induced by Ischemia -- Chapter 13. Role of NCX1 and NHE1 in Ventricular Arrhythmia -- Chapter 14. Gap Junctions and Cardiac Impulse Propagation. New Aspects of Arrhythmogenesis and Antiarrhythmic Agents T -- Chapter 15. Role of the T-Tubules in the Control of Cellular Calcium and Inotropic Interventions in Cardiac Ventricular Myocytes -- Chapter 16. Structure of Transverse (T)-tubules in Health and Disease -- Chapter 17. Enlightening Cardiac Arrhythmia with Optogenetics -- Part IV. Mechanisms of Acquired Arrhythmia -- Chapter 18. An Overview of Spiral- and Scroll-Wave Dynamics In Mathematical Models for Cardiac Tissue -- Chapter 19. The Role of Intracellular Ca2+ in Arrhythmias in the Postmyocardial Infarction Heart -- Chapter 20. Characteristics of Intracellular Ca2+ Handling Proteins in Heart Function in Health and Disease -- Chapter 21. Implications of Sarcolemmal Ca2+-handling Proteins in Heart Function in Health and Disease -- Chapter 22. Calmodulin Kinase II Regulation of Heart Rhythm and Disease -- Chapter 23. Pathways in Human Arrhythmias: Impact of Post-Translational Modifications -- Chapter 24. Viral Myocarditis -- Chapter 25. Epigenetic Influences of Air Pollution-Induced Cardiac Arrhythmias -- Part V. Mechanisms of Inherited Arrhythmia -- Chapter 26. The Short QT Syndrome -- Chapter 27. Defects in Ankyrin-Based Protein Targeting Pathways in Human Arrhythmia -- Part VI. Novel Antiarrhythmic Approaches -- Chapter 28. Ion Channels as New Drug Targets in Atrial Fibrillation -- Chapter 29. K Channel Openers as New Antiarrhythmic Agents.