1. An overview of metabonomics / John C. Lindon, Elaine Holmes and Jeremy K. Nicholson -- 2. Overview of biomarkers / John Timbrell -- 3. NMR spectroscopy : principles and instrumentation / Michael D. Reily and John C. Lindon -- 4. NMR spectroscopy of biofluids / John C. Lindon, Jeremy K. Nicholson and Elaine Holmes -- 5. 1H magic angle spinning NMR spectroscopy of tissues / Julian L. Griffin ... [et al.] -- 6. The application of metabonomics as an early in vivo toxicity screen / Gregory J. Stevens, Alan J. Deese and Donald G. Robertson -- 7. Strategies and techniques for the identification of endogenous and xenobiotic metabolites detected in metabonomic studies / John Shockcor and Ian D.Wilson -- 8. Multi- and megavariate data analysis : finding and using regularities in metabonomics data / Lennart Eriksson ... [et al.] -- 9. Use of metabonomics to study target organ toxicity / Craig E. Thomas, Elaine Holmes and Donald G. Robertson -- 10. Physiological variation in laboratory animals and humans / M.E. Bollard ... [et al.] -- 11. Environmental applications of metabonomic profiling / Jacob G. Bundy -- 12. Current challenges and future developments in metabonomics technology / Donald G. Robertson.