Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. Front Matter -- Contributions of Plasma Protein Binding and Membrane Transporters to Drug-Induced Mitochondrial Toxicity / Gavin P McStay -- The Role of Transporters in Drug Accumulation and Mitochondrial Toxicity / Kathleen M Giacomini, Huan-Chieh Chien -- Structure-Activity Modeling of Mitochondrial Dysfunction / Steve Enoch, Claire Mellor, Mark Nelms -- Mitochondria-Targeted Cytochromes P450 Modulate Adverse Drug Metabolism and Xenobiotic-Induced Toxicity / Haider Raza, F Peter Guengerich, Narayan G Avadhani -- Mitochondrial Dysfunction in Drug-Induced Liver Injury / Annie Borgne-Sanchez, Bernard Fromenty -- Evaluating Mitotoxicity as Either a Single or Multi-Mechanistic Insult in the Context of Hepatotoxicity / Amy L Ball, Laleh Kamalian, Carol E Jolly, Amy E Chadwick -- Cardiotoxicity of Drugs / Zoltan V Varga, Pal Pacher -- Skeletal Muscle Mitochondrial Toxicity / Eric K Herbert, Saul R Herbert, Karl E Herbert -- Manifestations of Drug Toxicity on Mitochondria in the Nervous System / Jochen H M Prehn, Irene Llorente-Folch -- Nephrotoxicity / Ana Belén Sanz, Maria Dolores Sanchez-Niño, Adrian M Ramos, Alberto Ortiz -- Mammalian Sperm Mitochondrial Function as Affected by Environmental Toxicants, Substances of Abuse, and Other Chemical Compounds / Sandra Amaral, Renata S Tavares, Sara Escada-Rebelo, Andreia F Silva, João Ramalho-Santos -- Biological and Computational Techniques to Identify Mitochondrial Toxicants / Robert B Cameron, Craig C Beeson, Rick G Schnellmann -- The Parallel Testing of Isolated Rat Liver and Kidney Mitochondria Reveals a Calcium-Dependent Sensitivity to Diclofenac and Ibuprofen / Sabine Schulz, Sabine Borchard, Tamara Rieder, Carola Eberhagen, Bastian Popper, Josef Lichtmannegger, Sabine Schmitt, Hans Zischka -- In Vitro Methodologies to Investigate Drug-Induced Toxicities / Rui F Simões, Teresa Cunha-Oliveira, Cláudio F Costa, Vilma A Sardão, Paulo J Oliveira -- Combined Automated Measurement of Respiratory Chain Complexes and Oxidative Stress / Marc Conti, Thierry Delvienne, Sylvain Loric -- Measurement of Mitochondrial Toxicity by Flow Cytometry / Padma Kumar Narayanan, Nianyu Li -- MitoChip / Varsha G Desai, G Ronald Jenkins -- Using 3D Microtissues for Identifying Mitochondrial Liabilities / Simon Messner, Olivier Frey, Katrin Rössger, Andy Neilson, Jens M Kelm -- Toward Mitochondrial Medicine / David A Dunn, Michael H Irwin, Walter H Moos, Kosta Steliou, Carl A Pinkert -- Measurement of Oxygen Metabolism In Vivo / M P J Diemen, R Ubbink, F M Münker, E G Mik, G J Groeneveld -- Detection of Mitochondrial Toxicity Using Zebrafish / Sherine S L Chan, Tucker Williamson -- MiRNA as Biomarkers of Mitochondrial Toxicity / Terry R Vleet, Prathap Kumar Mahalingaiah -- Biomarkers of Mitochondrial Injury After Acetaminophen Overdose / Benjamin L Woolbright, Hartmut Jaeschke -- Acylcarnitines as Translational Biomarkers of Mitochondrial Dysfunction / Richard D Beger, Sudeepa Bhattacharyya, Pritmohinder S Gill, Laura P James -- Mitochondrial DNA as a Potential Translational Biomarker of Mitochondrial Dysfunction in Drug-Induced Toxicity Studies / Afshan N Malik -- Predicting Off-Target Effects of Therapeutic Antiviral Ribonucleosides / Jamie J Arnold, Craig E Cameron -- Imaging of Mitochondrial Toxicity in the Kidney / Andrew M Hall, Joana R Martins, Claus D Schuh -- Imaging Mitochondrial Membrane Potential and Inner Membrane Permeability / Anna-Liisa Nieminen, Venkat K Ramshesh, John J Lemasters -- Quantifying Skeletal Muscle Mitochondrial Function In Vivo by 31P Magnetic Resonance Spectroscopy / Graham J Kemp -- Supplemental Images -- Front Matter -- Statin and Fibrate-Induced Dichotomy of Mitochondrial Function / Viruna Neergheen, Alex Dyson, Luke Wainwright, Iain P Hargreaves -- Friend or Foe / Sofia Annis, Adeel Safdar, Eduardo Biala, Ayesha Saleem, Housaiyin Li, Priya Gandhi, Zoe Fleischmann, Carmen Castaneda-Sceppa, Jonathan L Tilly, Dori C Woods, Konstantin Khrapko -- Involvement of Mitochondrial Dysfunction on the Toxic Effects Caused by Drugs of Abuse and Addiction / Daniel José Barbosa, João Paulo Capela, Maria Lourdes Bastos, Félix Carvalho -- Drug-Induced Mitochondrial Toxicity during Pregnancy / Diana Luz Juárez-Flores, Ana Sandra Hernández, Laura García-Otero, Mariona Guitart-Mampel, Marc Catalán-García, Ingrid González-Casacuberta, Jose César Milisenda, Josep Maria Grau, Francesc Cardellach, Constanza Morén, Glòria Garrabou -- Mitochondrial Toxicity in Children and Adolescents Exposed to Antiretroviral Therapy / Antoni Noguera-Julian, Eneritz Velasco-Arnaiz, Clàudia Fortuny -- Drug-Induced Mitochondrial Cardiomyopathy and Cardiovascular Risks in Children / Neha Bansal, Mariana Gerschenson, Tracie L Miller, Stephen E Sallan, Jason Czachor, Hiedy Razoky, Ashley Hill, Miriam Mestre, Steven E Lipshultz -- Role of Mitochondrial Dysfunction in Linezolid-Induced Lactic Acidosis / Alessandro Santini, Dario Ronchi, Daniela Piga, Alessandro Protti -- Metformin and Lactic Acidosis / Jean-Daniel Lalau -- Lessons Learned from a Phase I Clinical Trial of Mitochondrial Complex I Inhibition / Cecilia C Low Wang, Jeffrey L Galinkin, William R Hiatt -- Pharmacological Activation of Mitochondrial Biogenesis for the Treatment of Various Pathologies / Whitney S Gibbs, Natalie E Scholpa, Craig C Beeson, Rick G Schnellmann -- Mitochondrial Toxicity Induced by Chemotherapeutic Drugs / Luciana L Ferreira, Ana Raquel Coelho, Paulo J Oliveira, Teresa Cunha-Oliveira -- The Mitochondrial Exposome / Douglas I Walker, Kurt D Pennell, Dean P Jones -- Central Mitochondrial Signaling Mechanisms in Response to Environmental Agents / Young-Mi Go, Karan Uppal, Dean P Jones -- Detection of Mitochondrial Toxicity of Environmental Pollutants Using Caenorhabditis elegans / Laura L Maurer, Anthony L Luz, Joel N Meyer -- Persistent Organic Pollutants, Mitochondrial Dysfunction, and Metabolic Syndrome / Hong Kyu Lee, Youngmi Kim Pak -- Cigarette Smoke and Mitochondrial Damage / Jalal Pourahmad, Marjan Aghvami, Mohammad Hadi Zarei, Parvaneh Naserzadeh.