pt. 1. Computational approaches: Web resources for protein analysis ; Artificial neural networks for therapeutic protein engineering ; Phylogenetics and medicinal protein engineering ; Clustering and classification approaches to identifying protein properties ; Analysis of coordinated substitutions in proteins -- pt. 2. Protein engineering targets : vaccine: Tuning the immune response to our advantage : design of vaccines with tailored functions ; Modification of HIV-1 envelope glycoprotein to enhance immunogenicity ; Engineering better influenza vaccines : traditional and new approaches ; Construction of novel vaccines on the basis of virus-like particles : hepatitis B virus proteins as vaccine carriers ; Polyomavirus-derived virus-like particles ; Papillomavirus-derived virus-like particles ; Recombinant vaccines against hepatitis viruses -- pt. 3. Protein engineering targets: diagnostics and therapy: Designer diagnostic reagents and allergens ; Peptide-based diagnostic assays ; Recombinant antibodies ; Protein engineering for HIV therapeutics ; Recombinant enzymes with new and improved properties -- pt. 4. Special expression systems: Production of pharmaceutical compounds in plants ; Plant virus biotechnology platforms for expression of medicinal proteins ; Alphaviruses : multiplicity of vectors and their promising application as vaccines and cancer therapy agents.