chapter 1 Theoretical Basis of Isotope Effects from an Autobiographical Perspective -- chapter 2 Enrichment of Isotopes -- chapter 3 Comments on Selected Topics in Isotope Theoretical Chemistry -- chapter 4 Condensed Matter Isotope Effects -- chapter 5 Anharmonicities, Isotopes, and IR and NMR Properties of Hydrogen-Bonded Complexes -- chapter 6 Isotope Effects on Hydrogen-Bond Symmetrization in Ice and Strong Acids at High Pressure -- chapter 7 Hydrogen Bond Isotope Effects Studied by NMR -- chapter 8 Isotope Effects and Symmetry of Hydrogen Bonds in Solution: Single- and Double-Well Potential -- chapter 9 NMR Studies of Isotope Effects of Compounds with Intramolecular Hydrogen Bonds -- chapter 10 Vibrational Isotope Effects in Hydrogen Bonds -- chapter 11 Isotope Selective Infrared Spectroscopy and Intramolecular Dynamics -- chapter 12 Nonmass-Dependent Isotope Effects -- chapter 13 Isotope Effects in the Atmosphere -- chapter 14 Isotope Effects for Exotic Nuclei -- chapter 15 Muonium — An Ultra-Light Isotope of Hydrogen -- chapter 16 The Kinetic Isotope Effect in the Photo-Dissociation Reaction of Excited-State Acids in Aqueous Solutions -- chapter 17 The Role of an Internal-Return Mechanism on Measured Isotope Effects -- chapter 18 Vibrationally Enhanced Tunneling and Kinetic Isotope Effects in Enzymatic Reactions -- chapter 19 Kinetic Isotope Effects for Proton-Coupled Electron Transfer Reactions -- chapter 20 Kinetic Isotope Effects in Multiple Proton Transfer -- chapter 21 Interpretation of Primary Kinetic Isotope Effects for Adiabatic and Nonadiabatic Proton-Transfer Reactions in a Polar Environment -- chapter 22 Variational Transition-State Theory and Multidimensional Tunneling for Simple and Complex Reactions in the Gas Phase, Solids, Liquids, and Enzymes -- chapter 23 Computer Simulations of Isotope Effects in Enzyme Catalysis -- chapter 24 Oxygen-18 Isotope Effects as a Probe of Enzymatic Activation of Molecular Oxygen -- chapter 25 Solution and Computational Studies of Kinetic Isotope Effects in Flavoprotein and Quinoprotein Catalyzed Substrate Oxidations as Probes of Enzymic Hydrogen Tunneling and Mechanism -- chapter 26 Proton Transfer and Proton Conductivity in Condensed Matter Environment -- chapter 27 Mechanisms of CH-Bond Cleavage Catalyzed by Enzymes -- chapter 28 Kinetic Isotope Effects as Probes for Hydrogen Tunneling in Enzyme Catalysis -- chapter 29 Hydrogen Bonds, Transition-State Stabilization, and Enzyme Catalysis -- chapter 30 Substrate and pH Dependence of Isotope Effects in Enzyme Catalyzed Reactions -- chapter 31 Catalysis by Alcohol Dehydrogenases -- chapter 32 Effects of High Hydrostatic Pressure on Isotope Effects -- chapter 33 Solvent Hydrogen Isotope Effects in Catalysis by Carbonic Anhydrase: Proton Transfer through Intervening Water Molecules -- chapter 34 Isotope Effects from Partitioning of Intermediates in Enzyme-Catalyzed Hydroxylation Reactions -- chapter 35 Chlorine Kinetic Isotope Effects on Biological Systems -- chapter 36 Nucleophile Isotope Effects -- chapter 37 Enzyme Mechanisms from Isotope Effects -- chapter 38 Catalysis and Regulation in the Soluble Methane Monooxygenase System: Applications of Isotopes and Isotope Effects -- chapter 39 Secondary Isotope Effects -- chapter 40 Isotope Effects in the Characterization of Low Barrier Hydrogen Bonds -- chapter 41 Theory and Practice of Solvent Isotope Effects -- chapter 42 Enzymatic Binding Isotope Effects and the Interaction of Glucose with Hexokinase.