Mass spectrometry-based metabolomics in clinical and herbal medicines : strategies, technologies and applications

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Başlık:

Yazar:

Zhang, Aihua.

ISBN:

9783527835751

9783527835737

Yayın Bilgileri:

Weinheim, Germany : Wiley-VCH, 2022.

Fiziksel Tanımlama:

1 online resource (286 pages)

Genel Not:

Chapter 6 Metabolomics as Drivers for Biomarker Discovery and Mechanism Interpretation.

İçerik:

Cover -- Title Page -- Copyright -- Contents -- Preface -- Chapter 1 Current State of the Art of High-Throughput Metabolomics -- 1.1 Introduction -- 1.2 Metabolomics -- 1.3 Mass Spectrometry Technology -- 1.4 Recent Advancements and Applications -- 1.4.1 Disease Diagnoses and Metabolism -- 1.4.2 Metabolic Mechanisms -- 1.4.3 Drug Efficacy -- 1.4.4 Nutrition -- 1.4.5 Plant Biology -- 1.5 Limitation -- 1.6 Conclusions and Future Perspectives -- Acknowledgments -- References -- Chapter 2 Innovations in Analytical Techniques of Metabolomics -- 2.1 Introduction

2.2 Current Analytical Technologies of Metabolomics -- 2.3 Chromatography Platform -- 2.3.1 Gas Chromatography Technique -- 2.3.2 Liquid Chromatography Technique -- 2.3.3 Supercritical Fluid Chromatography Technique -- 2.3.4 Capillary Electrophoresis Chromatography Technique -- 2.4 Mass Spectrometry Platform -- 2.4.1 GC-MS Technique -- 2.4.2 LC-MS Technique -- 2.4.3 SFC-MS Technique -- 2.4.4 CE-MS Technique -- 2.5 Nuclear Magnetic Resonance Platform -- 2.6 Comprehensive and Multidimensional Analytical Platform -- 2.7 Conclusions -- Acknowledgments -- References

Chapter 3 Sample Preparation Method for Mass Spectrometry-Based Metabolomics -- 3.1 Introduction -- 3.2 Sample Collection and Storage -- 3.2.1 Urine -- 3.2.2 Plasma and Serum -- 3.2.3 Cerebrospinal Fluids -- 3.2.4 Tissue Homogenates -- 3.2.5 Saliva -- 3.3 Sample Preparation and Processing -- 3.4 Application -- 3.5 Future Development -- Acknowledgments -- References -- Chapter 4 Multivariate Data Analysis Approach for Mass Spectrometry-Based Metabolomics -- 4.1 Introduction -- 4.2 Separation-Based MS Techniques -- 4.2.1 Gas Chromatography-Mass Spectrometry

4.2.2 Liquid Chromatography-Mass Spectrometry -- 4.2.2.1 Reversed-Phase Liquid Chromatography-Mass Spectrometry -- 4.2.2.2 Hydrophilic Interaction Chromatography-Mass Spectrometry -- 4.2.2.3 Supercritical Fluid Chromatography-Mass Spectrometry -- 4.2.3 Capillary Electrophoresis-Mass Spectrometry -- 4.2.4 Ion Mobility-Mass Spectrometry -- 4.3 Separation-Free MS Techniques -- 4.3.1 Direct Infusion-Mass Spectrometry -- 4.3.2 Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry -- 4.3.3 Mass Spectrometry Imaging -- 4.3.4 Direct Analysis in Real Time-Mass Spectrometry

4.4 Tools for MS Result Analysis -- 4.5 Multivariate Statistical Analysis Approach for Data Analysis -- 4.6 Limitations and Challenges -- 4.7 Conclusions and Future Perspectives -- Acknowledgments -- References -- Chapter 5 Mass Spectrometry-Driven Metabolomics for Metabolites and Metabolic Pathway Analysis -- 5.1 Introduction -- 5.2 Mass Spectrometry-Driven Metabolomics for Biomarker Discovery -- 5.3 Data Extraction and Analysis for Metabolites and Metabolic Pathway -- 5.4 Biomarker Identification -- 5.5 Applications -- 5.6 Conclusions -- Acknowledgments -- References

Özet:

Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications.

Notlar:

John Wiley and Sons

Konu Terimleri:

Clinical chemistry.

Metabolites -- Spectra.

Metabolites -- Analysis.

Métabolites -- Spectre.

Métabolites -- Analyse.