This book constitutes the refereed proceedings of the Sescond Southwest Data Science Conference, SDSC 2023, held in Waco, TX, USa, during March 24-25, 2023. The 16 full and 1 short paper included in this book were carefully reviewed and selected from 72 submissions. They were oragnized in topical sections named: Business social and foundation data science; and applied data science, artifiicial intelligence and data engineering. .