This book of carefully selected research papers captures the essence of systems engineering. It offers readers a comprehensive exploration in the most recent applications and advancements of Axiomatic Design, a powerful method that elevates the level of product design and manufacturing. Although Axiomatic Design originated at the Massachusetts Institute of Technology (MIT) in Boston, it has been further developed by an active community of users and academics from all over the world. For the 15th time, the International Conference on Axiomatic Design convened global experts to discuss the core of the methodology. Their shared objective was to advance systems engineering, catering to the increasing complexity of modern product design. From over 85 submissions, the program committee selected 20 papers to ensure quality and relevance. Our profound gratitude extends to the contributing authors, whose research and dedication have shaped this collection, and to the program committee members for their unwavering commitment to academic integrity. Through their combined efforts, this document stands as a testament to the innovative spirit and academic excellence synonymous with systems engineering as developed by MIT.