Intro -- Title Page -- Copyright Page -- Contents -- Preface -- Part One Outcomes of Research -- Chapter 1 Pathways of the Research Innovator -- Diverse Outcomes of Science -- Best of Both Worlds: Scientific and Innovative -- Opportunities That Are Not Just Timely But Also Timeless -- Balancing Research and Innovation -- Essential Concepts of Research Innovation -- Research Innovation Pathways to Effects -- Learning from Award-winning Scientists and Serial Innovators -- Road to Meaningful Research Disclosure -- References -- Chapter 2 First Dimension: Scientific Impact -- Intellectual Impact and Scientific Pluralism -- You Cannot Make a Good Landing Out of a Bad Approach -- Intellectual Products of Scientific Endeavors -- Reality Means Reproducibility -- One May Not Know in the Beginning How the End Will Look Like -- References -- Chapter 3 Second Dimension: Public Health Value -- Improving Health in Mission Statements of Science -- The Road from Basic Research to Better Health -- Breaking Down Silos: Basic Science and Public Health -- Putting Science to Work and Change Lives -- High-impact Research Driven by Public Health Needs -- References -- Chapter 4 Third Dimension: Economic Development -- Economic Impact of Life Sciences Research -- Blockbuster Impact of University Research -- Good Science Must Come First in Commercialization -- Without Good Science, There Is No Positive Technology Transfer -- Impact of Life Sciences on the National Economy -- Diverse Messages About Economic Impact at Different Levels -- References -- Part Two Headwinds of Research Innovation -- Chapter 5 Slowdown and Erosion -- Signs of Slowdown in Research Innovation -- Obstacles to Research Innovation -- Increasing Costs of Regulatory Compliance -- The Gamble of Science and "Short-termism" -- Sputnik Moment: The Need to Accelerate Research -- References.

Chapter 6 Non-reproducible Research -- The Boulder of Non-reproducible Research -- Implications of Non-reproducible Results -- Sources of Non-repeatable Research Results -- The Undisclosed Becomes Non-repeatable -- Rare but Troubling: Pathological Science and Fraudulent Research -- The Way Out: Modeling, Transparency, and Continuous Quality Improvement -- References -- Chapter 7 Red Tape and Litigation -- Bureaucratization of Research -- Regulatory Burden on Creativity -- Protection of Intellectual Property -- Conflicts over Credit and Case Law of Inventor Recognition -- Accountability for Reproducibility -- References -- Part Three Boosters of Research Productivity -- Chapter 8 Humanism for Innovation -- Research Targeting by Values of Humanism -- Identifying Measures for Performance Improvement -- Creativity Needs Diversity of People, Cultures, and Ideas -- Rock Solid Values When the Controversies Mount -- Counteracting Flawed Economic and Social Incentives -- Focus and Motivation for Sacrificial Effort -- Numbers Need Stories and Stories Need Numbers -- References -- Chapter 9 Desire to Understand First -- We Will Surpass on the Gray Matter -- Research Talent Needs Scientific Opportunity -- Curiosity and Research Agenda -- Being Passionate Without Emotions -- The Power of Logic and Abstraction -- Creativity and Divergent Thinking -- Winning Science: Who Gets the Award? -- Reading Scientific Papers Can Be More Difficult Than Writing Them -- References -- Chapter 10 Learning from the Best -- The Benefits of Research Mentoring -- The Mentored Way to Success -- Mentoring Minority Students and Researchers -- Learn from Leaders to Become a Leader -- References -- Chapter 11 Cracking Public Health Needs -- Epidemiology Triggers Basic Research -- Scientific Assumptions Meet the Brutal Truth of Epidemics -- Curiosity-driven Research Enlists Epidemiology.

The Unparalleled Value of Retrospective Studies -- References -- Chapter 12 Engaged Research -- Science Confronts the Bubble Bias -- Resources and Indispensable Benefits of Engaged Research -- Prolific Partnerships of Arguers -- Talking Through to Achieve Understanding -- Academic Engagement with the Community -- Corporate Competence in Life Sciences -- Team Science and Collaborative Research -- Bouncing Ideas in the Real World -- References -- Chapter 13 Cross-cultural Convergence -- International Collaborations and Mobility -- Convergence of Disciplines -- Evolution of Team Science -- If You Have Never Been in Minority, You Have Never Said Anything Original -- References -- Chapter 14 Targeting and Repurposing -- Consequential Research Generates Value to Others -- Targeting Mechanisms Goes Beyond Observation -- Repurposing What Is Already Known -- Eureka Moment of Discovering the Unexpected -- From Serendipity to Practical Applications -- References -- Chapter 15 Trailblazing Technologies -- Behind Every Great Discovery, There Is an Elegant Methodology -- Sought-after Technique Becomes the Goal of Research -- The Technical Opportunity Presents Itself to the Researcher -- When the Engineer Decides to Serve Public Health -- References -- Chapter 16 Emulating Nature -- Scanning Nature for Valuable Compounds -- Studying How Nature Solves the Problem -- Learning from the Unexpected Outlier -- Intertwining Ring of Evidence -- References -- Chapter 17 Scientific Modeling -- Hallmarks of the Scientific Modeling -- Scholarly Intuition and Triple Evidence -- Validation and Refinement -- Choosing Models to Understand How Nature Works -- Understanding Processes Leads to Practical Solutions -- References -- Chapter 18 Mastering Bioentrepreneurship -- Catching the Semi-truck: Researcher Gets the First Large Grant.

Commercialization of Research Products and By-products -- Outreach, Elevator Pitch, and Marketing -- Planning for Customer Acquisition -- Pipeline of Life Sciences Innovation: Assets to Returns -- References -- Chapter 19 Art of Scientific Communication -- Yardstick of Communication: Original Research Report -- Learning from Examples and Feedback -- Evidence-based Writing: Sentences and Paragraphs -- Time-honored Structure of Scientific Manuscripts -- Quality Control: Testing the Manuscript Before Release -- Publishing a Research Paper Is Not "Mission Accomplished" -- References -- Part Four Atmosphere of Excellence -- Chapter 20 Quality and Performance Improvement -- Quality Control Looks at Populations and Organizations -- Cycle of Quality Improvement in the Research Enterprise -- Quality Disposition of Research Projects -- Measures of Success in Scientific Research -- References -- Chapter 21 Institutional and National Strategies -- Institutional Opportunities to Support Research -- Recruitment and Retention of Research Faculty -- Peer Comparisons of Research Productivity -- Catapults of Success: Education of the Youth -- Evidence-based Public Policies for the Knowledge Society -- References -- Chapter 22 International Collaboration and Competition -- The Flagship Role of Research Universities -- The Next Silicon Valleys: What Works and How It Works -- Scientific Innovation and Economic Competition -- International Variation in Research Policies -- Global Networks to Accelerate Research -- Innovative Minds with a Sense of Social and Global Responsibility -- References -- List of Award-winning Scientists and Serial Innovators -- Subject Index -- EULA.