chapter 1 Definitions of Itch -- chapter 2 Neurophysiologic Basis of Itch -- chapter 3 Pain and Itch -- chapter 4 Central Neural Mechanisms of Itch -- chapter 5 Animal Models of Itch: Scratching Away at the Problem -- chapter 6 Histamine-Induced Discriminative and Affective Responses Revealed by Functional MRI -- chapter 7 Central Nervous System Imaging of Itch with PET -- chapter 8 Skin Nerve Anatomy: Neuropeptide Distribution and Its Relationship to Itch -- chapter 9 Substance P and Itch -- chapter 10 Peripheral Opiate Receptor System in Human Epidermis and Itch -- chapter Figures -- chapter 11 Antipruritic Activity of a Novel K-Opioid Receptor Agonist, TRK-820 -- chapter 12 Putative Role of Cannabinoids in Experimentally Induced Itch and Inflammation in Human Skin -- chapter 13 Itch Models in Animals, with Special Emphasis on the Serotonin Modelin Rats -- chapter 14 Human Itch Models, with Special Emphasis on Itch in SLS-Inflamed and Normal Skin -- chapter 15 Microdialysis in Itch Research -- chapter 16 Measuring Nocturnal Scratching in Atopic Dermatitis -- chapter 17 Itch Questionnaires as Tools for Itch Evaluation -- chapter 18 Epidemiology of Itching In Skin and Systemic Diseases -- chapter 19 Uremic Pruritus: New Perspectives and Insights from Recent Trials -- chapter 20 Pruritus Complicating Liver Disease -- chapter 21 Itch In HIV-Infected Patients -- chapter 22 Neuropathic Pruritus -- chapter 23 Clinical Features of Itch in Atopic Eczema -- chapter 24 Postburn Itch -- chapter 25 Pruritus in Lichen Simplex Chronicus and Lichen Amyloidosis -- chapter 26 Treatment of Pruritus in Internal and Dermatological Diseases with Opioid Receptor Antagonists -- chapter 27 Prospects for a Novel K-Opioid Receptor Agonist, TRK-820, in Uremic Pruritus -- chapter 28 Treatment of Pruritic Skin Diseases with Topical Capsaicin -- chapter 29 Mechanistic and Clinical Assessment of Zangrado®, an Extract of the Amazonian Ethnomedicine Sangrede Grado, for the Treatment of Itch -- chapter 30 Reduction in Itch Severity with Topical Immunomodulators: A New Approach for Patients with Inflammatory Disease -- chapter 31 5-HT3 Receptor Antagonists as Antipruritics -- chapter 32 Cutaneous Nerve Stimulationin the Treatment of Localized Itch -- chapter 33 Psychosomatic Aspects of Pruritus -- chapter 34 On Psychological Factors Affecting Reports of Itch Perception -- chapter 35 Itching as a Focus of Mental Disturbance.