chapter 1. Melatonin production and bioavailability / Emel Oyku Cetin, Yigit Uyanikgil, Mehmet Turgut, and Meral Baka -- chapter 2. Deviations of melatonin levels and signaling in aging and diseases : options and limits of treatment / Rudiger Hardeland -- chapter 3. Pineal gland volume and melatonin / Niyazi Acer, Suleyman Karademir, and Mehmet Turgut -- chapter 4. Melatonin's beneficial effects in metabolic syndrome with therapeutic applications / Venkataramanujam Srinivasan, Yoshiji Ohta, Javier Espino, Rahimah Zakaria, and Mahaneem Mohamed -- chapter 5. Therapeutic applications of melatonin in pediatrics / Emilio J. Sanchez-Barcelo, Maria D. Mediavilla, and Russel J. Reiter -- chapter 6. Neuroprotective effect of melatonin on perinatal hypoxia-ischemia / Daniel Alonso-Alconada, Antonia Alvarez, and Enrique Hilario -- chapter 7. Melatonin as a therapeutic agent for sepsis / Edward H. Sharman and Stephen C. Bondy -- chapter 8. Melatonin's cardioprotective role / Alberto Dominguez-Rodriguez and Pedro Abreu-Gonzalez -- chapter 9. Melatonin : therapeutic value and neuroprotection in stroke / Max Franzblau, Nick Franzese, Gabriel S. Gonzales-Portillo, Chiara Gonzales-Portillo, Meaghan Staples, Mia C. Borlongan, Naoki Tajiri, Yuji Kaneko, and Cesar V. Borlongan -- chapter 10. Melatonin's antiapoptotic activity in neurodegenerative diseases / Xin Wang, Yingjun Guan, Wenyu Fu, Shuanhu Zhou, and Zheng-Hong Qin -- chapter 11. MT2 melatonin receptors : their role in sleep and neuropsychiatric disorders / Stefano Comai and Gabriella Gobbi -- chapter 12. Melatonin : its hepatoprotective actions and the role of melatonin receptors / Alexander M. Mathes -- chapter 13. Melatonin signaling in the control of Plasmodium development and replication / Alexandre Budu and Celia R.S. Garcia -- chapter 14. Melatonin : regulator of adult hippocampal neurogenesis / Gerardo B. Ramirez-Rodriguez and Leonardo Ortiz-Lopez -- chapter 15. Comparison of neuroprotective effect of melatonin in the nigrostriatal and mesolimbic dopaminergic systems of the zitter rat / Shuichi Ueda, Ayuka Ehara, Kenichi Inoue, Tomoyuki Masuda, Shin-ichi Sakakibara, and Kanji Yoshimoto -- chapter 16. Melatonin's neuroprotective role in Parkinson's disease / Venkataramanujam Srinivasan, Timo Partonen, Mahaneem Mohamed, Rahimah Zakaria, Asma Hayati Ahmad, Charanjit Kaur, Domenico De Berardis, Edward C. Lauterbach, Samuel D. Shillcutt, and U.S. Srinivasan --

chapter 17. Neuroprotective role of melatonin in glaucoma / Ruth E. Rosenstein, Maria C. Moreno, Pablo Sande, Marcos Aranda, Maria F. Gonzalez Fleitas, and Nicolas Belforte -- chapter 18. Melatonin receptors and their preventive role in carcinogenesis / Raffaela Santoro, Maria Ferraiuolo, Giovanni Blandino, Paola Muti, and Sabrina Strano -- chapter 19. Enhancement of antitumor activity of ursolic acid by melatonin in colon cancer cells / Wei Guo, Jingshu Wang, and Wuguo Deng -- chapter 20. Synthetic melatonin receptor ligands / Silvia Rivara, Marco Mor, Annalida Bedini, and Gilberto Spadoni -- chapter 21. Evaluation of synthetic melatonin analog antioxidant compounds / Sibel Suzen -- chapter 22. Melatonin's analogues in glaucoma / Hanan Awad Alkozi and Jesus Pintor -- chapter 23. Melatonergic drugs as therapeutic agents for insomnia and depressive disorders / Venkataramanujam Srinivasan, Domenico De Berardis, Amnon Brzezinski, Rahimah Zakaria, Zahiruddin Othman, Samuel D. Shillcutt, Edward C. Lauterbach, Gregory M. Brown, and Timo Partonen -- chapter 24. Agomelatine : a neuroprotective agent with clinical utility beyond depression and anxiety / Cecilio Alamo, Francisco Lopez-Munoz, and Pilar Garcia-Garcia -- chapter 25. Melatonergic antidepressant agomelatine in depressive and anxiety disorders / Domenico De Berardis, Michele Fornaro, Venkataramanujam Srinivasan, Stefano Marini, Nicola Serroni, Daniela Campanella, Gabriella Rapini, Luigi Olivieri, Felice Iasevoli, Alessandro Valchera, Giampaolo Perna, Maria Antonia Quera-Salva, Monica Mazza, Marilde Cavuto, Ida Potena, Giovanni Martinotti, and Massimo Di Giannantonio -- chapter 26. Effects of melatonin and melatonergic drugs in transgenic mouse models of Alzheimer's disease / Beatriz B. Otalora, M. Angeles Rol, and Juan A. Madrid -- chapter 27. Melatonin's mitochondrial protective role in Alzheimer's mice : role of melatonin receptors / Vedad Delic and Patrick C. Bradshaw -- chapter 28. Melatonin and its therapeutic implications in injuries of the developing brain and retina / Gurugirijha Rathnasamy, Eng-Ang Ling, and Charanjit Kaur -- chapter 29. Melatonin's protection against human prion-mediated neurotoxicity / Jae-Kyo Jeong and Sang-Youel Park -- chapter 30. Melatonin's protection against methamphetamine toxicity in neuroblastoma cells / Banthit Chetsawang --

chapter 31. Melatonin's beneficial effects on dopaminergic neurons in the rat model of Parkinson's disease / Manisha Gautam, Reshu Gupta, Ravinder Kumar Saran, and Bal Krishana -- chapter 32. Antiepileptic effects of melatonin / M. Hakan Seyithanoglu, Mehmet Turgut, Meliha Gundag Papaker, Mustafa Ayyildiz, Suleyman Kaplan, and Saffet Tuzgen -- chapter 33. Analgesic effects of melatonin / Selcuk Yavuz, Mehmet Turgut, Ozlem Yalcinkaya Yavuz, and Teoman Aydin -- chapter 34. Effects of melatonin on the Profiliferative and differentiative activity of neural stem cells / Saime Irkoren, Heval Selman Ozkan, and Mehmet Turgut -- chapter 35. Role of melatonin in collagen synthesis / Ozgur Taspinar, Mehmet Turgut, Engin Tastaban, and Teoman Aydin -- chapter 36. Melatonin use in peripheral nerve injury / Mehmet Emin Onger, Suleyman Kaplan, Ebru Elibol, Omur Gulsum Deniz, and Berrin Zuhal Altunkaynak -- chapter 37. Neuroprotective role of melatonin and its agonists : neuroprotective role of melatonin against dexamethasone-induced neurotoxicity / Aziza B. Shalby and Hanaa H. Ahmed -- chapter 38. Does melatonin have a protective role against side effects of nonsteroidal anti-inflammatory drugs? / Ebru Elibol, Berrin Zuhal Altunkaynak, Omur Gulsum Deniz, Mehmet Emin Onger, and Suleyman Kaplan -- chapter 39. Melatonin : pharmacological aspects and clinical trends / Emiliano Ricardo Vasconcelos Rios -- chapter 40. Protective effects of melatonin in radiation-induced nephrotoxicity / Eda Kucuktulu and Uzer Kucuktulu -- chapter 41. Melatonin and familial Mediterranean fever / Engin Tastaban, Mehmet Turgut, and Teoman Aydin -- chapter 42. Effects of melatonin on osteoblastic and osteoclastic activities of bone tissue / Meliha Gundag Papaker, M. Hakan Seyithanoglu, Mehmet Turgut, Suleyman Kaplan, and Saffet Tuzgen -- chapter 43. Phyto-melatonin : a novel therapeutic aspect of melatonin in nature's way / Chandana Haldar, Somenath Ghosh, and Amaresh Kumar Singh.