1. Regression models and their analysis -- 2. Convex design theory -- 3. Algorithms and numerical techniques -- 4. Optimal design under constraints -- 5. Nonlinear response models -- 6. Locally optimal designs in dose finding -- 7. Locally optimal designs in PK/PD studies -- 8. Adaptive model-based designs -- 9. Other applications of optimal designs -- 10. Useful matrix formulae.