1. Drug combination : much promise and many hurdles / Harry Yang and Laura Richman -- 2. Drug combination synergy / Harry Yang, Steven J. Novick, and Wei Zhao -- 3. Drug combination design strategies / Steven J. Novick and John J. Peterson -- 4. Confidence interval for interaction index / Maiying Kong and J. Jack Lee -- 5. Two-stage response surface approaches to modeling drug interaction / Wei Zhao and Harry Yang -- 6. A Bayesian industry approach to phase I combination trials in oncology / Beat Neuenschwander, Alessandro Matano, Zhongwen Tang, Satrajit Roychoudhury, Simon Wandel, Stuart Bailey -- 7. Statistical methodology for evaluation combination therapy in clinical trials / H.M. James Hung, Sue-Jane Wang -- 8. Challenges and opportunities in analysis of drug combination clinical trial data / Yaning Wang, Hao Zhu, Liang Zhao, and Ping Ji -- 9. Statistical computational tools for ADA analysis / Cheng Su.