Cell-penetrating peptides : design, development and applications

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Yazar:

Oba, Makoto, editor.

ISBN:

9783527835997

9783527836000

9783527836017

Fiziksel Tanımlama:

1 online resource : illustrations

İçerik:

Front Matter -- Introduction / Makoto Oba, Yosuke Demizu -- Classification / Makoto Oba -- Arginine-Rich Cell-Penetrating Peptides:Recent Advances of Design and Applications for Intracellular Delivery / Ikuhiko Nakase -- Cationic Peptide / Takashi Iwasaki -- Amphipathic Peptide / Makoto Oba -- Hydrophobic CPPs / Yosuke Demizu -- Foldamer / Takuma Kato -- Peptide Structure: Electrophysiological Analysis, Nuclear Magnetic Resonance Analysis, and Molecular Dynamics Simulation of Direct Penetration of Cell-Penetrating Peptides through Bilayer Lipid Membranes / Kayano Izumi, Batsaikhan Mijiddorj, Chihiro Saito, Izuru Kawamura, Ryuji Kawano -- Cellular Uptake Mechanisms of Arginine-Rich Cell-Penetrating Peptides / Ikuhiko Nakase -- Endosomal Escape / Austin R Prater, Jean-Philippe Pellois -- Pharmacokinetics of Therapeutic and Diagnostic Agents Conjugated with Cell-Penetrating Peptides / Takeshi Fuchigami, Masayuki Munekane, Kazuma Ogawa -- Drug Delivery / Takashi Misawa -- Peptide and Protein Delivery / Hidetomo Yokoo -- Cell-Penetrating Peptides for Nucleic Acid Delivery - An Update / Eric Vivès, Emilie Josse, Karidia Konate, Sébastien Deshayes, Prisca Boisguérin -- PPMOs: A Case Study for Cell-Penetrating Peptide Application / Scott Bittner, Zoe X Moulton, Hong M Moulton -- Cell-Penetrating Peptide-Conjugated Polymer Micelle for pDNA/siRNA Delivery / Takanori Kanazawa -- Lipid-Based Nanoparticles Using Cell-Penetrating Peptides / Ikramy A Khalil, Hideyoshi Harashima -- Cell-Penetrating Peptides as Tools to Facilitate Oral Delivery of Biopharmaceuticals / Camilla Jantzen Asgreen, Freja Fredholt, Hanne Mørck Nielsen, Mie Kristensen -- "Intranasal Delivery" / Noriyasu Kamei, Mariko Takeda-Morishita -- Clinical Trials / Makoto Oba -- Plant / Kousuke Tsuchiya, Keiji Numata -- Index

Özet:

Cell-Penetrating Peptides The definitive reference on the rational design of cell-penetrating peptides enables readers to develop tailor-made peptides for their specific needs. In recent years, cell-penetrating peptides (CPPs) have become valuable tools for the cellular delivery of proteins, nucleic acids, and drugs. These small peptide sequences can be artificially designed and synthesized with custom-made characteristics to mediate the efficient and non-toxic transport of biomolecules, drugs, or nanoparticles into the cell. Cell-Penetrating Peptides: Design, Development, and Applications provides an up-to-date account of the development and use of CPPs for delivering membrane-impermeable bioactive molecules into cells. Bringing together contributions from leading researchers from around the world, this comprehensive volume describes the characteristics and mechanisms of CPPs as well as their application in both medicine, biotechnology and agriculture. Covers rational design and development of cell-penetrating peptides for use in cellular delivery of small molecule drugs, proteins, nucleic acids, and nanoparticles Presents the chemical and biological characteristics of CPP action in vitro and in vivo Describes the structure and design principles of both synthetic and naturally occurring CPPs Discusses key medical applications of CPPs such as oral delivery, intranasal delivery, and clinical trials Cell-Penetrating Peptides: Design, Development, and Applications is an essential resource for biochemists, medicinal chemists, molecular biologists, biotechnologists, and researchers studying CPPs in both academia and industry.

Notlar:

John Wiley and Sons

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