Machine generated contents note: Chapter 1 -- Nervous System Functions of Poly(ADP-Ribose) Polymerase-1 -- Krishna Juluri, Hyo Chol Ha, and Solomon H. Snyder -- Chapter 2 -- Role of Poly(ADP-Ribose) Polymerase- 1 in Neurologic Disorders -- Marc E Poitras, Valina L. Dawson, and Ted M. Dawson -- Chapter 3 -- Involvement of PARP-1 and Poly(ADP-Ribosyl)ation in the Maintenance of -- Genomic Stability -- Cynthia M. Simbulan-Rosenthal, Dean S. Rosenthal, Bassem H. Haddad, -- Danith Ly, Jie Zhang, and Mark E. Smulson -- Chapter 4 -- Functional Testing of Human PARP in Proliferation, Endotoxic Shock, and -- Radiosensitivity: A Genetic Rescue Study. -- Zdenko Herceg, Virginie Petrilli, Anton Wutz, Berhard Auer, Marie-Pierre Cros, -- and Zhao-Qi Wang -- Chapter 5 -- PARP Inhibitors as Neuroprotective Agents for Brain Injury -- Joel H. Greenberg, Michelle C. LaPlaca, and Tracy K. Mclntosh -- Chapter 6 -- PARP Inhibitors and Cardioprotection -- Christoph Thiemermann, Nicole Wayman, Michelle C. McDonald, and -- Prabal Kumar Chatterjee -- Chapter 7 -- Neuroprotection of the Retina with 3-Aminobenzamide, a PARP Inhibitor -- Tim T Lam -- Chapter 8 -- Poly(ADP-Ribose) Polymerase Inhibitors and Acute Renal Failure -- Prabal Kumar Chatterjee and Christoph Thiemermann -- Chapter 9 -- Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Shock and Inflammation -- Csaba Szabd -- Chapter 10 -- Clinical Development of the Nicotinamides and Benzamides Involving PARP as a Molecular Target. -- Ronald W. Pero, Anders Olsson, Hanna Lindgren, and Tomas Leanderson -- Chapter 11 -- Chemoprotective Effect of a Novel PARP Inhibitor -- Gyorgy Rabloczky, Laszlo Jaszlits, Gyorgy Bardos, Balazs Sumegi, Kalman Tory, -- Ildiko Racz, Beatrix Farkas, Attila Sandor, Zoltan Berente, Erzsebet Osz, -- Judit Szilvassy, Istvan Sziklai, Sandor Bernath, and Peter Literati Nagy -- Chapter 12 -- Beneficial Effect of GPI 6150 Treatment in Multiple Animal Models of Diseases -- Jie Zhang -- Chapter 13 -- Protecting Effect of PARP Inhibition on Ultraviolet Light-Induced Skin Damage -- Beatrix Farkas, Balazs Sumegi, Gyorgy Rabloczky, Bela Csete, Balazs Hodosi, -- Marta Magyarlaki, Sandor Bernath, and Peter Literati Nagy -- Chapter 14 -- Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Diabetes Mellitus and Diabetic Vascular Dysfunction. -- Jon G. Mabley, Ldszlo Virdg, and Csaba Szabd -- Chapter 15 -- Therapeutic Targeting of the PARPs: Future Challenges, Future Opportunities -- Myron K. Jacobson and Elaine L. Jacobson.